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Cancer Risk Profile
Cancer genetic testing involves analyzing an individual's DNA to identify specific genetic changes linked to an increased risk of developing certain types of cancer. These tests aim to detect inherited genetic mutations that can predispose individuals to various cancer types, guiding decisions about screenings, prevention strategies, and potential treatments. The results inform risk assessment, family health history, and can guide personalized treatment approaches, especially in precision medicine.
Conditions and Genes
The table below outlines some key gene mutations and their associations with specific cancer conditions. It is important to note that these associations may vary, and genetic testing results should be interpreted by healthcare professionals. The table serves as a reference for understanding the genetic basis of certain cancers and can aid in targeted screening and treatment approaches.
Conditions | Genes |
---|---|
Mesothelioma | BAP1 |
Peutz-Jeghers Syndrome | STK11 |
Neurofibromatosis Type 1 | NF1 |
Hereditary Hemorrhagic Telangiectasia | SMAD4 |
Melanoma | CDKN2A, CDK4, BAP1, MITF, TERT, KIT |
Familial Atypical Multiple Mole Melanoma Syndrome | CDKN2A |
Breast Cancer | BRCA1, BRCA2, TP53, PTEN, PALB2, ATM, CHEK2, RAD51C, RAD51D, NBN, BARD1, CDH1, STK11, NF1, MSH6 |
Thyroid Cancer | PTEN |
Cowden Syndrome | PTEN |
Juvenile Polyposis Syndrome | BMPR1A, SMAD4 |
Lynch Syndrome | MLH1, MSH2, MSH6, PMS2, EPCAM |
Hereditary Diffuse Gastric Cancer | CDH1 |
Nervous System Tumors | NF1, TP53 |
Pancreatic Cancer | BRCA2, ATM, PALB2, CDKN2A, STK11, TP53 |
Bloom Syndrome | BLM |
Colorectal Cancer | APC, MUTYH, MLH1, MSH2, MSH6, PMS2, BMPR1A, SMAD4, POLD1, POLE, GREM1, BLM, CHEK2 |
Gastrointestinal Stromal Tumors (GIST) | KIT |
Endometrial Cancer | PTEN, MLH1, MSH2, MSH6, PMS2, EPCAM |
Ovarian Cancer | BRCA1, BRCA2, TP53, BRIP1, PALB2, RAD51C, RAD51D, MSH2, MLH1, STK11 |
Leukemia | NF1, TP53 |
Li-Fraumeni Syndrome | TP53 |
Familial Adenomatous Polyposis | APC |
Polyposis Syndromes | APC (Familial Adenomatous Polyposis), MUTYH (MUTYH-associated polyposis), POLD1, POLE (Polymerase proofreading-associated polyposis) |
Gastric Cancer | CDH1, STK11 |
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